Carcinomul glandei Bartholin-aspecte histologice

Dr. Priya Nagarajan, M.D., Ph.D. (cercetator dermatopatologie Ohio State University)

TRADUCERE DIN LB ENGLEZA

Descriere microscopica a Carcinomului glandei Bartholin:

Aspectul histologic al carcinoamelor variaza in functie de zona de origine:

  • Carcinomul scuamos si adenocarcinomul sint cele mai comune tumori maligne cu punct de pornire in glanda Bartholin (~40% fiecare tip), urmate de carcinomul adenoid chistic (~15%)
  • Alte tipuri histologice (~5%) includ:
    • Carcinomul cu celule de tranzitie, carcinomul adenoscuamos, carcinomul slab diferentiat, carcinomul epitelial/mioepitelial de grad scazut, sarcomul, melanomul si carcinomul cu celule clare
  • Carcinom scuamos:
    • De obicei apare din orificiul ductului vestibular sau dintr-o zona de tranzitie
    • Virusul papilomatos uman a fost identificat ca un factor major in carcinogeneza
    • De obicei bine diferentiat, compus din celule poligonale eozinofile keratinizate cu punti intercelulare
    • In tumorile bine diferentiate se observa frecvent perle de keratina
  • Adenocarcinomul:
    • Apare de obicei in zone de tranzitie sau din acini mucosi
    • Compus din celule columnare sau cuboidale cu acumulare de mucina intracelular
    • Pot fi prezente de asemenea acumulari de mucina extravazata
  • Carcinom adenoid chistic
    • Poate avea originea in celulele mioepiteliale
    • De obicei celulele tumorale au grad citologic scazut si sint aranjate intr-un model cribriform (spaţii chistice mici între celulele tumorale, cu aspect “ciuruit”), iar pseudo-lumenii sint umpluti cu mucina sau membrana bazala hialinizata (?)
    • Din cauza tendintei de invazie perineurala extensiva, carcinomul adenoid chistic da frecvente recurente locale

TEXTUL ORIGINAL IN LB ENGLEZA

 Micro description of Bartholin’s gland Carcinoma:

Histology of the carcinoma varies based on site of origin:

  • Squamous cell carcinomas (SCC) and adenocarcinomas are the most common malignant tumors arising from the Bartholin’s gland (~40% each), followed by adenoid cystic carcinoma (ACC, ~15%)
  • Other histological types (~5%) include:
    • Transitional cell carcinoma, adenosquamous carcinoma, poorly differentiated carcinoma, low grade epithelial- myoepithelial carcinoma, sarcoma, melanoma, and clear cell carcinoma
  • Squamous cell carcinoma:
    • Usually arises from vestibular duct orifice or at transition zone
    • Human papilloma virus infection has been identified as a major contributing factor in its carcinogenesis
    • Usually well differentiated, composed of polygonal eosinophilic, keratinizing cells with intercellular bridges
    • Keratin pearls are frequently noted in well differentiated tumors
  • Adenocarcinoma:
    • Frequently arises at transition zone or from mucin producing acini
    • Composed of columnar to cuboidal cells containing intracellular mucin
    • Pools of extravasated mucin may also be present
  • Adenoid cystic carcinoma:
    • May originate from myoepithelial cells
    • Tumor cells usually have low cytologic grade and are arranged in a cribriform pattern, and the (pseudo) lumens are filled with mucin or hyalinized basement membrane material
    • Because of its tendency for extensive perineural invasion, ACC is associated with frequent local recurrence”

IMAGINI CARCINOM GLANDA BARTHOLIN

Atentie!! Din cauza legii copyright-ului am postat toate linkurile incomplete.

Ca sa le accesati lipiti in fata linkurilor http://www.

(sau selectati, click dreapta si ”go to”-merge si asa)

Carcinom chistic adenoid

ncbi.nlm.nih.gov/pmc/articles/PMC3862213/figure/f0015/

(A: The mass had a lobular structure and showed infiltrative proliferation (Hematoxylin & Eosin staining × 20). B: The tumor cells were relatively homogeneous, small and circular to oval in shape containing a nucleus with densely stained chromatin. The nucleus-to-cytoplasm ratio was high (Hematoxylin & Eosin staining × 200). C: The tumor cells proliferated in an alveolar pattern, forming many large and small pseudocysts, with mucus-filled lumens, and showed a cribriform pattern (Hematoxylin & Eosin staining × 100). D: The tumor cells showed infiltrative proliferation into the surrounding soft tissue. No perineural infiltration, considered to be characteristic of Bartholin’s tumors, was detected (Hematoxylin & Eosin staining × 40).)

pathologyoutlines.com/caseofweek/case172image1.jpg

pathologyoutlines.com/caseofweek/case172image2.jpg

pathologyoutlines.com/caseofweek/case172image3.jpg

pathologyoutlines.com/caseofweek/case172image4.jpg

pathologyoutlines.com/caseofweek/case172image5.jpg

Adenocarcinom: 

  • Adenocarcinom mucinos bine diferentiat

a.) jjco.oxfordjournals.org/content/31/5/226/F2/graphic-2.large.jpg

b.) jjco.oxfordjournals.org/content/31/5/226/F2/graphic-3.large.jpg

Microscopic findings by H&E staining. A well-differentiated mucinous adenocarcinoma is shown. The squamous mucosal surface was partially broken by the tumor which extended from the submucosal tissue [(a), ×45]. The tumor cells had abundant cytoplasm and prejudiced nuclei floated loosely or fence-like in a mucinous lake. Formation of cancer lumen was poor. Some of the tumor cells had crescent-shaped nuclei, the so-called signet ring-type cells [(b), ×225]

jjco.oxfordjournals.org/content/31/5/226/F3.large.jpg

(Immunohistochemical expression of CA19-9. CA19-9 was focally expressed both in the cytoplasm and on the cell membrane of tumor cells (×400).)

jjco.oxfordjournals.org/content/31/5/226/F4.large.jpg

(The expression of CEA was present in the cytoplasm of almost all the tumor cells (×400).)

jjco.oxfordjournals.org/content/31/5/226/F5.large.jpg

(p53 protein expressed in the nuclei of the tumor cells (×400). Signet ring-type tumor cells were positive for p53 staining.)

jjco.oxfordjournals.org/content/31/5/226/F6.large.jpg

(MIB-1 antigen expressed in the nuclei of the tumor cells (×400). Signet ring-type tumor cells were negative for MIB-1 staining.)

  • Adenocarcinom apocrin

ncbi.nlm.nih.gov/pmc/articles/PMC3804815/figure/fig001/

(A) Unremarkable epidermis with tumor bulk in dermis 40×; B) Abundant mitotic activity and focal necrosis 100×; C) CEA 100×; D) CK7 100×; E) EMA 100×; F) GCDFP 100×.)

Carcinom scuamos

flickr.com/photos/40764007@N08/12908234553/in/photostream/

flickr.com/photos/40764007@N08/12908574854/in/photostream/

flickr.com/photos/40764007@N08/12908154785/in/photostream/

flickr.com/photos/40764007@N08/12908582484/in/photostream/

flickr.com/photos/40764007@N08/12908149805/in/photostream/

flickr.com/photos/40764007@N08/12908246143/in/photostream/

flickr.com/photos/40764007@N08/12908158215/in/photostream/

flickr.com/photos/40764007@N08/12908243513/in/photostream/

flickr.com/photos/40764007@N08/12908162105/in/photostream/

flickr.com/photos/40764007@N08/12908253013/

flickr.com/photos/40764007@N08/12908249983/in/photostream/

flickr.com/photos/40764007@N08/12908164725/

Imagini microscop electronic

ijpmonline.org/viewimage.asp?img=IndianJPatholMicrobiol_2010_53_1_171_59221_u1.jpg

(adenosquamous variant of bartholin gland carcinoma showing nests of tumor cells undergoing central comedo-necrosis (H and E; x 100))

ijpmonline.org/viewimage.asp?img=IndianJPatholMicrobiol_2010_53_1_171_59221_u2.jpg

(dark and light secretory granules characteristi c of bartholin gland (TEM; x 5000)

Anunțuri

Lasă un răspuns

Completează mai jos detaliile tale sau dă clic pe un icon pentru a te autentifica:

Logo WordPress.com

Comentezi folosind contul tău WordPress.com. Dezautentificare / Schimbă )

Poză Twitter

Comentezi folosind contul tău Twitter. Dezautentificare / Schimbă )

Fotografie Facebook

Comentezi folosind contul tău Facebook. Dezautentificare / Schimbă )

Fotografie Google+

Comentezi folosind contul tău Google+. Dezautentificare / Schimbă )

Conectare la %s

Cecile's Cuisine

A Blog about Easy, Healthy yet Delicious Recipes for Working Moms like me.

40 Something

What's next?

Zona de criza

In si dincolo de crize

Sergiu Somesan

Proza fantastica si SF

DermPath Daily

Devoted to what everyone loves to see more of...SKIN!

ISTORII REGĂSITE

Probabil cel mai bun blog de istorie!

Bisofficiallan

World in your eyes!

Lucy Visinescu's Blog

Informatii si sfaturi despre dinti si nu numai

Violeta Balan

De la o zi la alta

Semizeea

Cine poate sau are curaj să încerce să-i răpească femeii plăcerea de a se contrazice, de a se răzgândi și încă a avea dreptate, de a acționa contrar logicii proprii?

COJOCARII

Blog de Familie

windowscoolsecrets

Just another WordPress.com site

Liga pentru Sanatate

Locul de discutii al celor care isi doresc ca sistemul sanitar din Romania sa isi recapete demnitatea si valoarea

%d blogeri au apreciat asta: